Question: 155. Match List I with List II :
| List I | List II |
|---|---|
| A. Down’s syndrome | I. 11^{\text {th }} chromosome |
| B. \alpha-Thalassemia | II. ‘X’ chromosome |
| C. \beta-Thalassemia | III. 21^{\text {st }} chromosome |
| D. Klinefelter’s syndrome | IV. 16^{\text {th }} chromosome |
Choose the correct answer from the options given below :
(1) A-I, B-II, C-III, D-IV
(2) A-II, B-III, C-IV, D-I
(3) A-III, B-IV, C-I, D-II
(4) A-IV, B-I, C-II, D-III
Answer: Option (3)
Explanation:
Down’s syndrome is caused due to trisomy of the 21^{\text {st }} chromosome,
so A matches with III.
\alpha-Thalassemia occurs due to deletion or mutation of genes present on the 16^{\text {th }} chromosome, so B matches with IV.
\beta-Thalassemia is caused by mutation in the \beta-globin gene located on the 11^{\text {th }} chromosome, so C matches with I.
Klinefelter’s syndrome is a sex chromosome aneuploidy characterized by an extra ‘X’ chromosome,
so D matches with II.
Therefore, the correct matching is A-III, B-IV, C-I, D-II, corresponding to option (3).